Therapeutic Nicotine

ADD / ADHD / Attention

 

#TherapeuticNicotine #SNEWS

“Together, these findings have led to the hypothesis that individuals with ADHD may smoke in order to alleviate requisite symptoms of the disorder…”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3353150/

——————————————–

#TherapeuticNicotine #SNEWS

“The results support the self-medication hypothesis for nicotine in adults with ADHD.”

https://pubmed.ncbi.nlm.nih.gov/20025370/

——————————————–

#TherapeuticNicotine #SNEWS

“Non-smoking young adults with ADHD-C showed improvements in cognitive performance following nicotine administration in several domains that are central to ADHD.”

https://www.sciencedirect.com/science/article/abs/pii/S0091305707003048

——————————————–

#TherapeuticNicotine #SNEWS

“The results showed nicotine-induced improvement on some measures of sustained attention in the low attention group…which suggests that nicotine tends to optimize rather than improve performance on cognitive tasks.”

https://www.sciencedirect.com/science/article/abs/pii/S0031938405005627

——————————————–

#TherapeuticNicotine #SNEWS

“This study shows that, in addition to reducing attentional impairment, nicotine administered via transdermal patches can improve attentiveness in normal adult non-smokers.”

https://pubmed.ncbi.nlm.nih.gov/9860103/

——————————————–

#TherapeuticNicotine #SNEWS

“Because improvements occurred among nonsmokers, the nicotine effect appears not to be merely a relief of withdrawal symptoms. It is concluded that nicotine deserves further clinical trials with ADHD.”

https://pubmed.ncbi.nlm.nih.gov/8741955/

——————————————–

 

Alzheimer / Dementia / MCI

“The secondary outcome measures showed significant nicotine-associated improvements in attention, memory, and psychomotor speed, and improvements were seen in patient/informant ratings of cognitive impairment.”

#TherapeuticNicotine #SNEWS

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466669/

——————————————–

“Nicotine’s effects on cognitive functioning have shown it to increase perception, visual attention,and arousal as well as improving the speed and accuracy of motor functioning.”

#TherapeuticNicotine #SNEWS

https://www.tandfonline.com/doi/abs/10.1080/13607860220126808

——————————————–

“Research has revealed that chronic exposure to nicotine produces an unusual up-regulation of the nicotinic receptor sites. This increase …is thought to provide some protection against neuro-degenerative disorders.”

#TherapeuticNicotine #SNEWS

https://www.tandfonline.com/doi/abs/10.1080/13607860220126808

——————————————–

“Acute nicotine administration can improve performance of patients with AD on cognitive tasks, including verbal learning and memory, attention in a continuous performance task, and accuracy in a visual attention task.”

#TherapeuticNicotine #SNEWS

https://pubmed.ncbi.nlm.nih.gov/12436427/

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine has been shown to protect against neurotoxic insult in vitro/in vivo. This suggests that nicotine has a dual effect on brain function following aging or injury such that it can rescue function of remaining neurons.”

https://pubmed.ncbi.nlm.nih.gov/12436427/

——————————————

Nicotine may have therapeutic uses

#TherapeuticNicotine #SNEWS

“Drug companies have often refused to fund legitimate and valid research into the potential therapeutic use of nicotine owing to its association with smoking and its image of an abusable drug.”

https://pubmed.ncbi.nlm.nih.gov/9006184/

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine significantly improved sustained visual attention (in both RVIP and DRMLO tasks), reaction time (in both FT and RVIP tasks), and perception (CFF task–both ascending and descending thresholds).”

https://pubmed.ncbi.nlm.nih.gov/1410164/

——————————————

#TherapeuticNicotine #SNEWS

“When chronically taken, nicotine may result in enhancement of performance, and protection against Alzheimer’s disease (other diseases mentioned in study).”

https://pubmed.ncbi.nlm.nih.gov/1859921/

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine in patients with dementia of the Alzheimer type (DAT) produced a significant and marked improvement in discriminative sensitivity and reaction times on a computerised test of attention and information processing.”

https://pubmed.ncbi.nlm.nih.gov/2597885/

——————————————

 

Aphthous ulcers

#TherapeuticNicotine #SNEWS

“The theory that nicotine is known as the protective factor is also supported by three case reports, in which aphthous ulcers were prevented or healed while the patients used nicotine replacement materials.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387635/

——————————————

#TherapeuticNicotine #SNEWS

“In addition, nicotine or its metabolites can result in decrease of pro-inflammatory cytokines… Consequently, there is reduced susceptibility to RAS due to immunosuppression and/or reduction in inflammatory response.”

https://www.sciencedirect.com/science/article/abs/pii/S0306987711001691

——————————————

#TherapeuticNicotine #SNEWS

“This study shows that a group of recurrent aphthous stomatitis (RAS) patients is significantly less likely to contain smokers than a matched control population.”

https://pubmed.ncbi.nlm.nih.gov/12108762/

——————————————

#TherapeuticNicotine #SNEWS

“We describe a woman with Behçet’s syndrome characterized by recurrent aphthous ulcers… Therapy with a nicotine patch led to a regression of all aphthous ulcers within a few days.”

https://www.nejm.org/doi/10.1056/NEJM200012143432418

——————————————

#TherapeuticNicotine #SNEWS

“The aim of this study was to investigate the effect of nicotine (Nicorette tablets), on aphthous ulcers in non-smoking patients. This preliminary trial shows that nicotine may have a beneficial effect on aphthous ulcers.”

https://onlinelibrary.wiley.com/doi/abs/10.5694/j.1326-5377.1991.tb121180.x

——————————————

 

Auditory

#TherapeuticNicotine #SNEWS

“The present results support the hypothesis that nicotine enhances auditory processing, but this enhancement is task-dependent.”

https://www.nature.com/articles/s41598-021-92588-z

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine improves auditory performance in difficult listening situations. The present results support future investigation of nicotine effects in clinical populations with auditory processing deficits.”

https://pubmed.ncbi.nlm.nih.gov/31832719/

——————————————

 

Autism

#TherapeuticNicotine #SNEWS

“Our results also suggest that transdermal nicotine may have a beneficial effect on aggression, irritability, and sleep in ASD, though the sample size of this study is too small to make definitive conclusions.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394231/

——————————————

 

Behcet’s disease

#TherapeuticNicotine #SNEWS

“We describe five ex-smoker Behcet’s Disease patients… 4 out of 5 patients quickly responded to nicotine-patch therapy and experienced a complete regression of all mucocutaneous lesions within 6 months of observation.”https://academic.oup.com/rheumatology/article/49/3/501/1786816

——————————————

 

Brain Injury / Disease

#TherapeuticNicotine #SNEWS

“…animal studies suggest that nicotine as a pharmacological agent may augment recovery of cognitive deficits caused by TBI” [Traumatic Brain Injury].

https://pubmed.ncbi.nlm.nih.gov/35138210/

——————————————

#TherapeuticNicotine #SNEWS

“Several studies have shown that nicotine treatment can attenuate cognitive deficits produced by medial septal lesions, lesions of the nucleus basalis, and traumatic brain injury.”

https://pubmed.ncbi.nlm.nih.gov/15681815/

——————————————

 

Cancer / Cancer Treatments

#TherapeuticNicotine #SNEWS

Nicotine inhibits ovarian cancer cell ERK and p38 MAPK signaling.  Nicotine inhibits ovarian cancer proliferation and spheroid invasion.

https://www.sciencedirect.com/science/article/abs/pii/S001448272030416X

——————————————

#TherapeuticNicotine #SNEWS

“Intraperitoneal nicotine administration controls neuropathic pain evoked by traumatic or toxic nervous system alterations.”

https://www.sciencedirect.com/science/article/abs/pii/S0014299913003270

——————————————

#TherapeuticNicotine #SNEWS

“These results support the nAChR modulation as a possible therapeutic approach to the complex, undertreated chemotherapy-induced neuropathies.”

https://www.sciencedirect.com/science/article/abs/pii/S0014299913003270

——————————————

 

Cognitive / IQ

#TherapeuticNicotine #SNEWS

“Nicotine improves sustained attention and reduces distractor interference, promoting cognitive stability. Nicotine enhances response times without differential impact on task switching or distraction.”

https://www.sciencedirect.com/science/article/abs/pii/S0306452220304723

——————————————

#TherapeuticNicotine #SNEWS

“Preclinical models and human studies have demonstrated that nicotine has cognitive-enhancing effects. Attention, working memory, fine motor skills and episodic memory functions are particularly sensitive to nicotine’s effects.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6018192/

——————————————

#TherapeuticNicotine #SNEWS

“The first study to demonstrate that the nicotine e-cigarette can improve working memory.”

https://pubmed.ncbi.nlm.nih.gov/22503574/

——————————————

#TherapeuticNicotine #SNEWS

“Compared to placebo, nicotine and donepezil significantly improved…overall flight performance. Both cholinergic drugs showed the largest effects on flight tasks requiring sustained visual attention.”

https://www.nature.com/articles/1300202

——————————————

#TherapeuticNicotine #SNEWS

“APM scores were significantly higher… suggesting that nicotine acts to enhance physiological processes underlying performance on intellectual tasks.”

https://link.springer.com/article/10.1007/BF02245346

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine improves attention in a wide variety of tasks plus immediate and longer term memory in healthy volunteers.

Nicotine improves attention in patients with probable Alzheimer’s Disease.”

https://pubmed.ncbi.nlm.nih.gov/1579636/

——————————————

 

Digestive Tract / Bowel

#TherapeuticNicotine #SNEWS

“In this relatively small study of patients with active Crohn’s colitis, 6 mg nicotine enemas appeared to be of clinical benefit in most patients.”

https://www.hindawi.com/journals/grp/2008/237185/

——————————————

#TherapeuticNicotine #SNEWS

“This review provides evidence that transdermal nicotine is superior to placebo (fake patch) for the treatment of active ulcerative colitis.”

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD004722.pub2/full

——————————————

#TherapeuticNicotine #SNEWS

“If administered in combination with mesalazine, nicotine is superior to placebo in promoting clinical remission of ulcerative colitis of mild to moderate degree.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2014383/

——————————————

 

Down’s Syndrome

#TherapeuticNicotine #SNEWS

“Improvements possibly related to attention and information processing were seen for Down’s syndrome patients… Our preliminary findings are encouraging, although not generalizable because of small numbers.”

https://pubmed.ncbi.nlm.nih.gov/11052587

——————————————

#TherapeuticNicotine #SNEWS

“These results suggest that stimulating central nicotinic receptors might have an acute cognitive benefit in young adult Down syndrome subjects.”

https://link.springer.com/chapter/10.1007/978-3-7091-6262-0_19

——————————————

 

Endurance / Exercise / Athletic Performance

#TherapeuticNicotine #SNEWS

“We conclude that nicotine prolongs endurance by a central mechanism that may involve nicotinic receptor activation and/or altered activity of dopaminergic pathways.”

https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/expphysiol.2006.033373

——————————————

 

Huntington’s Disease

#TherapeuticNicotine #SNEWS

“These results clearly showed neuroprotective effect of nicotine in experimental model of Huntington’s Disease. The clinical relevance of these findings in HD patients remains unclear and warrants further studies.”

https://pubmed.ncbi.nlm.nih.gov/16140176/

——————————————

 

Mental Health – Behavior Issues

#TherapeuticNicotine #SNEWS

“Clinical trials and case series report anti-aggressive effects of nicotine. Here we argue that the nAChR system…may also be a key target for modulation of aggressive behaviors.”

https://www.sciencedirect.com/science/article/abs/pii/S0028390819305003

——————————————

#TherapeuticNicotine #SNEWS

“Our study provides evidence for the feasibility and tolerability of transdermal nicotine in a small sample of adults with severe Autism Spectrum Disorder symptoms and pathological chronic aggression and irritability.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6394231/

——————————————

 

Mental Health – Depression

#TherapeuticNicotine #SNEWS

“E-cigarette use was not associated with an escalation in depression symptoms.”  “E-cigarette use was not related to the development of depression symptoms over time.”

https://www.sciencedirect.com/science/article/abs/pii/S0376871621005676

——————————————

#TherapeuticNicotine #SNEWS

“It is postulated that smokers are protected from the consequences of these changes, while they continue to smoke, by the antidepressant properties of nicotine.”

https://www.sciencedirect.com/science/article/abs/pii/S0091305700002057

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine improves cognitive performance in clinical and preclinical studies.”  “Nicotine may also benefit depressive symptoms and depressive behavior.”

https://www.sciencedirect.com/science/article/abs/pii/S0149763417301793

——————————————

#TherapeuticNicotine #SNEWS

“Cognitive and mood benefits may be mediated by nicotinic effect on neural networks.  Nicotine’s effects on networks may reverse network changes seen in depression.”

https://www.sciencedirect.com/science/article/abs/pii/S0149763417301793

——————————————

#TherapeuticNicotine #SNEWS

“Through modulation of intrinsic functional networks, nAChR agonists may reduce depressive symptoms, enhance emotional regulation ability, and improve cognitive deficits common in LLD.”

https://www.sciencedirect.com/science/article/abs/pii/S0149763417301793

——————————————

#TherapeuticNicotine #SNEWS

“These results indicate that nicotine normalizes dysfunctional cortico-striatal communication in unmedicated non-smokers with MDD (major depressive disorder).”

https://pubmed.ncbi.nlm.nih.gov/29795403/

——————————————

#TherapeuticNicotine #SNEWS

“We observed robust response (86.7%) and remission rates (53.3%). There was a significant decrease in MADRS (Montgomery-Asberg Depression Rating scale)…”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6129985/

——————————————

#TherapeuticNicotine #SNEWS

“These findings suggest a role for nicotinic receptor systems in the pathophysiology of depression and that nicotinic compounds should be evaluated for treating depression symptoms.”

https://pubmed.ncbi.nlm.nih.gov/16977477/

——————————————

#TherapeuticNicotine #SNEWS

“Acute administration of nicotine patches produced rapid eye movement sleep (REM) increases in non-smoking major depressed patients as well as clinical improvement in mood.”

https://pubmed.ncbi.nlm.nih.gov/11995405/

——————————————

#TherapeuticNicotine #SNEWS

“Antidepressant effect was also observed after four continuous days of nicotine administration.”

https://pubmed.ncbi.nlm.nih.gov/11995405/

——————————————

#TherapeuticNicotine #SNEWS

“The data strongly implicate the involvement of central nicotinic receptors in the depressive characteristics of the FSL rats, and suggest that nicotinic agonists may have therapeutic benefits in depressive disorders”

https://link.springer.com/article/10.1007/s002130050879

——————————————

#TherapeuticNicotine #SNEWS

“These findings suggest that nicotine receptor activation may be important in major depression and shows for the first time that nicotine patches may be useful in the treatment of depression.”

https://pubmed.ncbi.nlm.nih.gov/9592048/

——————————————

#TherapeuticNicotine #SNEWS

“Results of the visual analog scale and HAM-D showed a significant improvement in depression after the second day of nicotine patches.”

https://pubmed.ncbi.nlm.nih.gov/9746444/

——————————————

 

Mental Health – OCD (Obsessive Compulsive Disorder)

#TherapeuticNicotine #SNEWS

“Nicotine may ameliorate OC symptoms in severe, treatment-refractory OCD patients. Although encouraging, these initial positive effects should be tested in large controlled studies.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7528475/

——————————————–

 

Mental Health – Schizophrenia

#TherapeuticNicotine #SNEWS

“Our results suggest the high prevalence of nicotine use in schizophrenia may be an attempt to correct a network deficit known to interfere with cognition.”

https://www.frontiersin.org/articles/10.3389/fpsyt.2022.804055/full

————————————

#TherapeuticNicotine #SNEWS

“A high strength nicotine e-cigarette has the potential to help people with schizophrenia spectrum disorders to quit or reduce smoking. “

https://academic.oup.com/ntr/article/23/7/1113/6168972

——————————————

#TherapeuticNicotine #SNEWS

“Cognitive and early sensory alterations are core features of schizophrenia. A single dose of nicotine can improve those features in patients. Attention domain is the most responsive to nicotine in patients.”

https://www.sciencedirect.com/science/article/abs/pii/S0149763420305042

——————————————

#TherapeuticNicotine #SNEWS

“…tobacco cigarette smoking represents an attempt at self-medication in schizophrenia, because the additional nicotine so provided alleviates the hypofunctional sensory gating seen in this illness.”

https://pubmed.ncbi.nlm.nih.gov/19328631/

——————————————

 

Movement Disorders (not diagnosis specific)

#TherapeuticNicotine #SNEWS

“Moreover, these results suggest that cNIC treatment may alleviate motor symptoms and/or delay the deterioration of motor function in movement disorders by blocking aberrant motor learning.”

https://pubmed.ncbi.nlm.nih.gov/27170121/

——————————

#TherapeuticNicotine #SNEWS

“Overall, the above findings, coupled with nicotine’s neuroprotective effects, suggest that nAChR drugs have potential for future drug development for movement disorders.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4149916/

——————————————

 

Multiple Sclerosis

#TherapeuticNicotine #SNEWS

“This study provides evidence that nicotine alters the infiltration of proinflammatory monocytes and neutrophils into the CNS of EAE mice via multiple nAChRs…”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4760232/

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine administration after the development of EAE symptoms prevented further disease exacerbation, suggesting that it might be useful as an EAE/MS therapeutic”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4176721/

——————————————

#TherapeuticNicotine #SNEWS

“Due to the proven therapeutic effect of nicotine on AD  and PD, we decided to study the role of nicotine in EAE as an animal model of MS…nicotine might be recommended as a promising drug for MS therapy.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3659034/

——————————————

 

Narcolepsy

#TherapeuticNicotine #SNEWS

“We found evidence that nicotine, administered as a dermal patch… is a fast-acting and relatively safe drug to relieve the symptom burden of severely affected patients suffering from all types of narcolepsy.”

https://www.authorea.com/doi/full/10.22541/au.162126605.51833119

——————————————–

#TherapeuticNicotine #SNEWS

“Based on these findings, we believe further investigation is warranted to look at the role of nicotine in treatment of both cataplexy and excessive daytime sleepiness in narcoleptics.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3311418/

——————————————

#TherapeuticNicotine #SNEWS

“After he did not respond to traditional therapies, a nicotine patch was prescribed with success. “

#Narcolepsy

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2823281/

——————————————

 

Oral / Jaw

#TherapeuticNicotine #SNEWS

“In surgeries performed under local anaesthesia are in agreement with data…that have reported the effectiveness of nicotine in the control of postoperative pain following surgery under general anaesthesia.”

https://pubmed.ncbi.nlm.nih.gov/32381373/

—————————————–

 

Pain / Analgesic

#TherapeuticNicotine #SNEWS

“The pooled effect sizes for both pain threshold and tolerance revealed that nicotine…produced acute pain-inhibitory effects that may be characterized as small to medium in magnitude.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4912401/

——————————————

#TherapeuticNicotine #SNEWS

“Nicotine decreased neuropathic pain induced by repeated intraperitoneal administration of the anticancer agent oxaliplatin (2.4 mg/kg), lowering the hypersensitivity to mechanical and thermal stimuli.”

https://www.sciencedirect.com/science/article/abs/pii/S0014299913003270

——————————————-

#TherapeuticNicotine #SNEWS

“Intraoperative use of intranasal nicotine has a sustained opioid-sparing effect in non-smoking women undergoing gynaecological procedures and is associated with a higher frequency of nausea.”

https://journals.lww.com/ejanaesthesiology/Fulltext/2011/08000/Randomised_trial_of_intranasal_nicotine_and.7.aspx

——————————————-

#TherapeuticNicotine #SNEWS

“The preoperative application of a 7 mg nicotine patch resulted in a significant reduction in postoperative opioid consumption in nonsmoking men undergoing RRP”

https://journals.lww.com/anesthesia-analgesia/Fulltext/2008/09000/Transdermal_Nicotine_for_Analgesia_After_Radical.48.aspx

———————————————–

#TherapeuticNicotine #SNEWS

“Nicotine administration prevented isoflurane-induced hyperalgesia without altering the antinociception produced by higher isoflurane concentrations.” (in mice)

https://pubmed.ncbi.nlm.nih.gov/12131122/

—————————————————

 

Parkinson Disease

#TherapeuticNicotine #SNEWS

“Women with greater dietary nicotine intake had a lower risk of PD than those with lower intake.”

https://academic.oup.com/ajcn/article/112/4/1080/5876214

———————————————–

#TherapeuticNicotine #SNEWS

Nicotine “may enhance function lost with nigrostriatal damage. This possibility stems from results showing that chronic nicotine treatment improved striatal integrity and function.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2046219/

————————————————–

 

Psoriasis

#TherapeuticNicotine #SNEWS

“Psoriasis is an immune-mediated disease… [These data demonstrate] the possibility that novel anti-inflammatory treatments such as nicotine replacement therapy…could have a beneficial effect on patients with psoriasis…”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3325452/

—————————————–

 

Pyoderma Gangrenosum

#TherapeuticNicotine #SNEWS

“Two patients with pyoderma gangrenosum treated with topical nicotine 0.5% w/w cetamacrogol formula A cream are described here, both of whom had dramatic clinical resolution of their pyoderma gangrenosum.”

https://pubmed.ncbi.nlm.nih.gov/15204166/

—————————————

#TherapeuticNicotine #SNEWS

“Herein we describe a patient with pyoderma gangrenosum who responded twice to topical nicotine within 4 weeks and 3 months, respectively, without any adverse effects.”

https://jamanetwork.com/journals/jamadermatology/fullarticle/189304

—————————————–

#TherapeuticNicotine #SNEWS

“Nicotine chewing gum may not only be beneficial in treating pyoderma gangrenosum but may also be useful in treating other skin disorders with prominent neutrophilic infiltrations…”

https://sci-hub.st/10.1111/j.1346-8138.1995.tb03904.x

—————————————-

 

Sarcoidosis

#TherapeuticNicotine #SNEWS

“…there are epidemiologic and immunologic data to support the use of nicotine in the treatment of sarcoidosis and results in other immune-mediated diseases.”

https://journal.chestnet.org/article/S0012-3692(21)01282-4/fulltext

————————————-

#TherapeuticNicotine #SNEWS

“Nicotine treatment was well tolerated in patients with active pulmonary sarcoidosis, and the preliminary findings of this pilot study suggest that it may reduce disease progression, based on FVC.”

https://journal.chestnet.org/article/S0012-3692(21)00962-4/fulltext

————————————-

#TherapeuticNicotine #SNEWS

“The immune phenotype of patients with symptomatic sarcoidosis treated with nicotine closely resembled that of asymptomatic patients, supporting the notion that nicotine treatment may be beneficial in this patient population.”

https://journal.chestnet.org/article/S0012-3692(13)60095-1/fulltext

—————————————

 

Seizures / Epilepsy

#TherapeuticNicotine #SNEWS

“According to current clinical experience, patients with uncontrolled ADSHE harboring relevant mutations should be offered precision treatment with transdermal nicotine.”

https://pubmed.ncbi.nlm.nih.gov/34763266/

———————————————-

#TherapeuticNicotine #SNEWS

“Nevertheless, the two siblings reported here add to the small number of pediatric case reports regarding the successful use of nicotine patches in ADSHE.”

https://www.pedneur.com/article/S0887-8994(21)00147-8/fulltext

———————————————-

#TherapeuticNicotine #SNEWS

“Treatment with a nicotine patch can be an effective therapy in epilepsy patients with nAChR gene variants.”

https://pubmed.ncbi.nlm.nih.gov/33284031/

————————————————

#TherapeuticNicotine #SNEWS

“Nicotine appears to be a mechanistic treatment for this specific disorder, probably because of desensitization of the mutated receptors.”

https://pubmed.ncbi.nlm.nih.gov/32097883/

——————————————————-

#TherapeuticNicotine #SNEWS

“We report resolution of an epileptic encephalopathy by administration of transdermal nicotine patches in an adolescent with severe nonlesional refractory frontal lobe epilepsy.”

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2012.03715.x

————————————————–

#TherapeuticNicotine #SNEWS

…in this individual with refractory ADNFLE, nicotine had a therapeutic effect on seizures, and it may be useful to others with this disorder.”

https://onlinelibrary.wiley.com/doi/full/10.1046/j.1528-1157.2003.58102.x-i1 

————————————————–

 

Sleep Apnea

#TherapeuticNicotine #SNEWS

“When chronically taken, nicotine may result in: …and protection against; (5) Parkinson’s disease (6) Tourette’s disease (7) Alzheimers disease, (8) ulcerative colitis and (9) sleep apnea.”

https://pubmed.ncbi.nlm.nih.gov/1859921/

——————————————-

#TherapeuticNicotine #SNEWS

“It was concluded that nicotine reduces apneas during the early hours of sleep, and this effect may be caused by its stimulating action on upper airway muscles.”

https://pubmed.ncbi.nlm.nih.gov/3965253/

——————————————-

 

Spinal Cord Injury

#TherapeuticNicotine #SNEWS

“This data may have significant therapeutic implications for the targeting of nicotine receptors in the treatment of compressive spinal cord trauma.”

https://onlinelibrary.wiley.com/doi/10.1002/jnr.21901

———————————————-

 

Tourette Syndrome

#TherapeuticNicotine #SNEWS

“…there is no doubt that the understanding of nicotine on brain-behavior relationships and in drug development for neuropsychiatric disorders will have been advanced for the next generation of researchers.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4597915/

——————————————

#TherapeuticNicotine #SNEWS

“Secondary efficacy measures, including patient self-reports and parental ratings, found nicotine to reduce complex tics and improve behaviors related to inattention.”

https://pubmed.ncbi.nlm.nih.gov/15132126/

——————————————

#TherapeuticNicotine #SNEWS

“These findings confirm earlier open-label findings and suggest that combining nicotinic receptor modulation and neuroleptics could be a therapeutic option for the treatment of Tourette’s disorder”

https://pubmed.ncbi.nlm.nih.gov/11681767/

——————————————

#TherapeuticNicotine #SNEWS

“Within 24 hr of the application of a single 7-mg TNP (nicotine patch), the severity and frequency of tic symptoms is significantly decreased over baseline.”

https://www.sciencedirect.com/science/article/abs/pii/S0163725896001994

——————————————

#TherapeuticNicotine #SNEWS

“While there was a broad range in individual response, application of the TNP produced significant reductions in Yale Global Tic Severity Scale (YGTSS) scores relative to baseline”

https://pubmed.ncbi.nlm.nih.gov/8973070/

——————————————

#TherapeuticNicotine #SNEWS

“Chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic treatment alone.”

https://www.sciencedirect.com/science/article/abs/pii/002432058990444X